Singapore legislation
Schedule 1
Schedule 1
First Schedule Biological Agents
FIRST SCHEDULESections 2, 6, 7(1), (2) and (3), 8, 9(1) and (2), 10, 11, 12(1), (2) and (3), 13, 27(1), (2) and (3), 28(1), (2), (3) and (4), 29(1), 38, 42(3), 44, 45(2), 46, 47(6), 62, 63(3) and (4) and the Fourth ScheduleFirst Schedule Biological AgentsPart 1BACTERIA1.Brucella canis2.Chlamydia psittaci (avian strains)3.Mycobacterium canettii4.Mycobacterium africanum5.Mycobacterium bovis (non-BCG strains)6.Mycobacterium microti7.Mycobacterium tuberculosis8.Any biological agent that is a constructed or reconstructed replication‑competent form of any bacterium set out in this PartFUNGI1.Blastomyces dermatitidis2.Histoplasma capsulatum var. capsulatum3.Histoplasma capsulatum var. duboisii4.Paracoccidioides brasiliensis5.Coccidioides immitis6.Coccidioides posadasii, except for the following attenuated strains:
∆chs5; and
∆cts2/∆ard1/∆cts37.Any biological agent that is a constructed or reconstructed replication‑competent form of any fungus set out in this PartVIRUSES1.Arenaviridae(a)Lymphocytic choriomeningitis virus(b)Mopeia virus(c)LCM-Lassa complex viruses (except Lassa virus)(d)Flexal virus2.Bunyaviridae(a)Akabane virus(b)California encephalitis virus(c)Oropouche virus(d)Hantaviruses (e)Bhanja virus(f)Nairobi sheep disease virus(g)Heartland virus(h)Severe Fever Thrombocytopenia Syndrome Virus3.Flaviviridae(a)Japanese encephalitis virus (except for the vaccine strain 14-14-2 virus)(b)Murray Valley encephalitis virus(c)Rocio virus(d)St. Louis encephalitis virus(e)Wesselsbron virus(f)West Nile virus(g)Louping ill virus(h)Negishi virus(i)Powassan virus4.Herpesviridae(a)Herpesvirus ateles5.Orthomyxoviridae(a)Dhori virus(b)Thogoto virus(c)Influenza A virus subtype H5N1(d)Influenza A virus subtype H7N96.Picornaviridae(a)Poliovirus, except for the following vaccine strains:
sabin Type-1;
sabin Type-2; and
sabin Type-37.Reoviridae(a)Orungo virus8.Retroviridae(a)Human immunodeficiency virus (HIV) Types 1 and 2, except for any HIV lentiviral vector system which has at least 2 of the following features:
the U3 region of the 3’LTR in the transfer vector is absent or altered, which results in a stable self‑inactivating (SIN) configuration; (ii)the HIV genes for packaging function are split to a minimum of 2 packaging plasmids (excluding the env plasmid); (iii)the vpr, vpu, vif and nef genes are either absent or altered to be non‑functional; or
the vector system requires minimally 4‑recombination to achieve Replication Competent Lentivirus (RCL)(b)Human T lymphotropic virus (HTLV) Types 1 and 2(c)Simian immunodeficiency virus9.Rhabdoviridae(a)Rabies virus(b)Vesicular stomatitis virus (except Indiana vesiculovirus and New Jersey vesiculovirus)10.Togaviridae(a)Everglades virus(b)Getah virus(c)Mucambo virus(d)Ndumu virus(e)Semliki forest virus(f)Tonate virus(g)Western equine encephalitis virus11.Unconventional agents associated with the transmission of Spongiform Encephalitis(a)Bovine spongiform encephalopathy prion and other related animal transmissible spongiform encephalopathy prion(b)Gerstmann-Straussler-Scheinker syndrome prion(c)Kuru prion(d)Creutzfeldt-Jakob disease prion(e)Variant Creutzfeldt-Jakob disease prion(f)Fatal familial insomnia prion12.Any biological agent that is a constructed or reconstructed replication‑competent form of any virus set out in this PartPart 2BACTERIA1.Bacillus anthracis, except for the attenuated strains devoid of —
plasmid pX02; or
plasmids pX01 and pX022.Bacillus cereus biovar anthracis3.Brucella abortus, except for the attenuated strains —
19; or
RB514.Brucella melitensis5.Brucella suis6.Burkholderia mallei7.Burkholderia pseudomallei8.Clostridium botulinum9.Franciscella tularensis, except for the attenuated strains of —
the subspecies of novicida (the UTAH 112 [ATCC 15482]);
the subspecies of holartica live vaccine strain [ATCC 29684]; or
the B38 strain [ATTC 6223]10.Yersinia pestis, except for the attenuated strains devoid of —
Pgm locus [EV76 strain];
75 kb low-calcium response virulence plasmid [Tjiwidej S strain]11.Any biological agent that is a constructed or reconstructed replication‑competent form of any bacterium set out in this PartRICKETTSIAE1.Coxiella burnetii (except for the attenuated Phase II, plaque purified clone 4 of the Nine Mile strain)2.Rickettsia — all species3.Any biological agent that is a constructed or reconstructed replication‑competent form of any rickettsia set out in this PartVIRUSES1.Bunyaviridae(a)Rift Valley fever virus (except for the vaccine strain MP‑12)2.Coronaviridae(a)Middle East Respiratory Syndrome Coronavirus (MERS CoV)(b)Severe Acute Respiratory Syndrome Coronavirus (SARS CoV), formerly known as SARS Coronavirus(c)Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‑CoV‑2), also known as Coronavirus Disease 2019 (COVID‑19) virus3.Flaviviridae(a)Yellow fever virus (except for the vaccine strain 17‑D)4.Poxviridae(a)Monkeypox virus5.Togaviridae(a)Eastern equine encephalitis virus(b)Venezuelan equine encephalitis virus6.Any biological agent that is a constructed or reconstructed replication‑competent form of any virus set out in this Part.[S 676/2007; S 573/2009; S 541/2011; S 396/2015; S 652/2017; S 71/2020; S 139/2020; S 87/2021]