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Approval by institutional animal care and use committee of use of animal for scientific purpose

Animals and Birds (Care and Use of Animals for Scientific Purposes) Rules

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—(1) A person must not use any animal for any scientific purpose before written approval for a project relating to such use is granted by an institutional animal care and use committee in accordance with paragraph (3) or (3C), as the case may be.(2) An institutional animal care and use committee shall not grant its approval for a proposed project or for any significant change to an ongoing project unless the committee is satisfied, upon conducting a review of the components of the project, that the care and use of the animal will comply with the following requirements:(a)any procedure involving the animal will be carried out in a manner that will avoid or minimise discomfort, pain or distress caused to the animal;(b)the investigator has considered alternatives to any procedure that may cause more than momentary or slight pain or distress to the animal and has provided a written and narrative description of the methods and sources used to determine that such alternatives are not available;(c)the investigator has provided written assurance that the project does not unnecessarily duplicate previous experiments;(d)the investigator has provided a justification for the endpoints of the experiments to be carried out in the project;(e)the rationale for involving animals and the appropriateness of the species and the number of animals to be used justifies such use of the animals in the project;(f)any procedure that may cause more than momentary or slight pain or distress to the animal —(i)will be carried out in consultation with the attending veterinarian;(ii)will not include the use of paralytics without anaesthesia; and(iii)will be performed with appropriate sedatives, anaesthetics or analgesics, unless the withholding of such agents is justified for scientific reasons by the investigator in writing and will be continued for only the necessary period of time;(g)the animal will undergo euthanasia as soon as possible if it experiences severe or chronic pain or distress that cannot be relieved;(h)the personnel who will conduct procedures on the animal are appropriately qualified and trained in such procedures and any trainee involved in the conduct of such procedures will be under appropriate supervision;(i)in the case of any project that involves surgery, appropriate pre-operative and post-operative care for the animal will be provided in accordance with established veterinary practices and all survival surgery will be performed using aseptic procedures and aseptic techniques;(j)the animal will not be used in more than one experiment, unless the subsequent experiment is justified for scientific reasons by the investigator in writing and such repeated use of the animal complies with the guidelines; and(k)the attending veterinarian is consulted on the use of appropriate euthanasia on the animal.(3) An institutional animal care and use committee may approve a project relating to any proposal (not being a proposal assigned for DMR) —(a)after the proposal is reviewed at a meeting of the committee convened in accordance with the guidelines; and(b)by a vote of a majority of the quorum at that meeting.(3A) An institutional animal care and use committee must develop a policy on the types of proposals that may be reviewed by designated members of the committee having regard to the following:(a)a review by a meeting of the committee in accordance with paragraph (3) is the preferred method of review;(b)the types of proposals assigned for DMR include, but are not limited to, proposals relating to —(i)projects using small numbers of animals with procedures not expected to result in pain or distress caused to the animals;(ii)projects using only non-survival surgery; and(iii)projects involving only euthanasia for tissue harvest.(3B) An institutional animal care and use committee may assign a proposal to be reviewed by designated members of the committee if —(a)the proposal is first given to the committee for consideration; and(b)the committee decides unanimously that the proposal is to be a proposal assigned for DMR.(3C) Any approval granted by an institutional animal care and use committee for a project relating to a proposal assigned for DMR is valid if the approval has been granted —(a)after the designated members of the committee have reviewed the proposal; and(b)by the unanimous decision of the designated members of the committee.(3D) If a project relating to a proposal assigned for DMR is not approved in accordance with paragraph (3C), the proposal —(a)must subsequently be reviewed at a meeting of the institutional animal care and use committee convened in accordance with the guidelines; and(b)may be approved by the vote of a majority of the quorum at that meeting.(4) An institutional animal care and use committee shall notify the relevant investigator and licensee in writing of —(a)any decision of the committee to approve or withhold approval of any project relating to the care and use of any animal for any scientific purpose; or(b)any modification to the proposed project required in order to secure the approval of the committee in respect of such project.(5) If a member of an institutional animal care and use committee has any interest, directly or indirectly —(a)in any project the proposal for which is being reviewed or approved by the committee; or(b)in any other matter that can give rise to a conflict of interest on his part as such member in the review or approval of any project,he shall disclose the nature of his interest at the meeting of the committee and shall not take part in any deliberation of the committee with respect to that project.(6) If an institutional animal care and use committee suspends a project involving the use of any animal for any scientific purpose, the licensee shall, in consultation with the institutional animal care and use committee —(a)review the reasons for the suspension;(b)take appropriate corrective action; and(c)where directed to do so by the Director-General, report that action with a full explanation thereof to the Director-General.

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