Regulation 10

any procedure involving the animal will be carried out in a manner that will avoid or minimise discomfort, pain or distress caused to the animal;

the investigator has considered alternatives to any procedure that may cause more than momentary or slight pain or distress to the animal and has provided a written and narrative description of the methods and sources used to determine that such alternatives are not available;

the investigator has provided written assurance that the project does not unnecessarily duplicate previous experiments;

the investigator has provided a justification for the endpoints of the experiments to be carried out in the project;

the rationale for involving animals and the appropriateness of the species and the number of animals to be used justifies such use of the animals in the project;

any procedure that may cause more than momentary or slight pain or distress to the animal —

will be carried out in consultation with the attending veterinarian;

will not include the use of paralytics without anaesthesia; and

will be performed with appropriate sedatives, anaesthetics or analgesics, unless the withholding of such agents is justified for scientific reasons by the investigator in writing and will be continued for only the necessary period of time;

the animal will undergo euthanasia as soon as possible if it experiences severe or chronic pain or distress that cannot be relieved;

the personnel who will conduct procedures on the animal are appropriately qualified and trained in such procedures and any trainee involved in the conduct of such procedures will be under appropriate supervision;

in the case of any project that involves surgery, appropriate pre-operative and post-operative care for the animal will be provided in accordance with established veterinary practices and all survival surgery will be performed using aseptic procedures and aseptic techniques;

the animal will not be used in more than one experiment, unless the subsequent experiment is justified for scientific reasons by the investigator in writing and such repeated use of the animal complies with the guidelines; and

the attending veterinarian is consulted on the use of appropriate euthanasia on the animal.

after the proposal is reviewed at a meeting of the committee convened in accordance with the guidelines; and

by a vote of a majority of the quorum at that meeting.

a review by a meeting of the committee in accordance with paragraph (3) is the preferred method of review;

the types of proposals assigned for DMR include, but are not limited to, proposals relating to —

projects using small numbers of animals with procedures not expected to result in pain or distress caused to the animals;

projects using only non-survival surgery; and

projects involving only euthanasia for tissue harvest.

the proposal is first given to the committee for consideration; and

the committee decides unanimously that the proposal is to be a proposal assigned for DMR.

after the designated members of the committee have reviewed the proposal; and

by the unanimous decision of the designated members of the committee.

must subsequently be reviewed at a meeting of the institutional animal care and use committee convened in accordance with the guidelines; and

may be approved by the vote of a majority of the quorum at that meeting.

any decision of the committee to approve or withhold approval of any project relating to the care and use of any animal for any scientific purpose; or

any modification to the proposed project required in order to secure the approval of the committee in respect of such project.

in any project the proposal for which is being reviewed or approved by the committee; or

in any other matter that can give rise to a conflict of interest on his part as such member in the review or approval of any project,he shall disclose the nature of his interest at the meeting of the committee and shall not take part in any deliberation of the committee with respect to that project.

review the reasons for the suspension;

take appropriate corrective action; and

where directed to do so by the Director-General, report that action with a full explanation thereof to the Director-General.